Transforming growth factor-β induces development of the TH17 lineage

@article{Mangan2006TransformingGF,
  title={Transforming growth factor-$\beta$ induces development of the TH17 lineage},
  author={P. Mangan and L. Harrington and Darrell B. O'Quinn and Whitney S. Helms and D. Bullard and C. Elson and R. D. Hatton and S. Wahl and T. Schoeb and C. Weaver},
  journal={Nature},
  year={2006},
  volume={441},
  pages={231-234}
}
A new lineage of effector CD4+ T cells characterized by production of interleukin (IL)-17, the T-helper-17 (TH17) lineage, was recently described based on developmental and functional features distinct from those of classical TH1 and TH2 lineages. Like TH1 and TH2, TH17 cells almost certainly evolved to provide adaptive immunity tailored to specific classes of pathogens, such as extracellular bacteria. Aberrant TH17 responses have been implicated in a growing list of autoimmune disorders. TH17… Expand

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