Transforming growth factor β-induced peritoneal fibrosis is mouse strain dependent.

  title={Transforming growth factor β-induced peritoneal fibrosis is mouse strain dependent.},
  author={Peter J Margetts and C. Michael Hoff and Limin Liu and Ron Korstanje and Louise Walkin and Angela Summers and Sarah Herrick and Paul E. C. Brenchley},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={28 8},
BACKGROUND Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis. The etiology is unclear, but genetic predisposition may be a contributing factor. We used adenovirus-mediated gene transfer of transforming growth factor (TGF) β1 to the peritoneum in four genetically distinct laboratory mouse strains to assess differences in fibrogenic response. METHODS Mice from four genetic backgrounds (C57BL/6J, DBA/2J, C3H/HeJ and SJL/J) received an… CONTINUE READING
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