Transforming growth factor-β in breast cancer: too much, too late

@article{BarcellosHoff2009TransformingGF,
  title={Transforming growth factor-β in breast cancer: too much, too late},
  author={Mary Helen Barcellos-Hoff and Rosemary J. Akhurst},
  journal={Breast Cancer Research : BCR},
  year={2009},
  volume={11},
  pages={202 - 202}
}
The contribution of transforming growth factor (TGF)β to breast cancer has been studied from a myriad perspectives since seminal studies more than two decades ago. Although the action of TGFβ as a canonical tumor suppressor in breast is without a doubt, there is compelling evidence that TGFβ is frequently subverted in a malignant plexus that drives breast cancer. New knowledge that TGFβ regulates the DNA damage response, which underlies cancer therapy, reveals another facet of TGFβ biology that… CONTINUE READING

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