Transforming growth factor-β in T-cell biology

  title={Transforming growth factor-β in T-cell biology},
  author={Leonid Gorelik and Richard A Flavell},
  journal={Nature Reviews Immunology},
Strict control of T-cell homeostasis is required to permit normal immune responses and prevent undesirable self-targeted responses. Transforming growth factor-β (TGF-β) has been shown to have an essential role in that regulation. Owing to its broad expression, and inhibitory effects on multiple cell types of the immune system, TGF-β regulation is complex. Through advances in cell-specific targeting of TGF-β signalling in vivo, the role of TGF-β in T-cell regulation has become clearer. Recent in… CONTINUE READING

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