Transforming growth factor-β and breast cancer: Transforming growth factor-β/SMAD signaling defects and cancer

@article{Kretzschmar2000TransformingGF,
  title={Transforming growth factor-β and breast cancer: Transforming growth factor-β/SMAD signaling defects and cancer},
  author={Marcus Kretzschmar},
  journal={Breast Cancer Research : BCR},
  year={2000},
  volume={2},
  pages={107 - 115}
}
Transforming growth factor-β (TGF-β) is a tumor suppressor, the function of which is compromised in many types of human cancer, including breast cancer. The tumor suppressive effects of TGF-β are caused by potent inhibition of cell proliferation due to cell cycle arrest in the G1 phase. Such antiproliferative responses are mediated by a signaling system that includes two types of cell surface receptors and intracellular signal transducers, the SMAD proteins. Different molecular mechanisms can… CONTINUE READING

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