Transforming growth factor-β Does Not Induce Endothelin-1 Secretion in Primary Cultured Human Tenon's Fibroblasts

Subconjunctival fibrosis is closely related to scarring after glaucoma filtering surgery, and transforming growth factorβ (TGF-β) is known to play a crucial role in this scarring process. It induces the transformation of fibroblasts to myofibloblasts and the production of extracellular matrix (ECM) in the Tenon’s capsule. Endothelin-1 (ET-1) is thought to… (More)