Transforming growth factor-β 1 stimulates vascular smooth muscle cell L-proline transport by inducing system A amino acid transporter 2 ( SAT 2 ) gene expression

@inproceedings{ENSENATTransformingGF,
  title={Transforming growth factor-β 1 stimulates vascular smooth muscle cell L-proline transport by inducing system A amino acid transporter 2 ( SAT 2 ) gene expression},
  author={Diana ENSENAT and Saamir HASSAN and Sylvia V. REYNA and Andrew I. SCHAFER and William DURANTE}
}
  • Diana ENSENAT, Saamir HASSAN, +2 authors William DURANTE
Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that contributes to arterial remodelling by stimulating vascular smooth muscle cell (SMC) growth and collagen synthesis at sites of vascular injury. Since -proline is essential for the synthesis of collagen, we examined whether TGF-β1 regulates the transcellular transport of -proline by vascular SMCs. Proline uptake by vascular SMCs was primarily sodium-dependent, pH-sensitive, blocked by neutral amino acids and… CONTINUE READING