Transforming growth factor-β 1 enhances the invasiveness of breast cancer cells by inducing a Smad2-dependent epithelial-to-mesenchymal transition.

@article{Lv2013TransformingGF,
  title={Transforming growth factor-$\beta$ 1 enhances the invasiveness of breast cancer cells by inducing a Smad2-dependent epithelial-to-mesenchymal transition.},
  author={Zhidong Lv and B. Kong and Jian-guo Li and Hui-Li Qu and Xin-gang Wang and Weihong Cao and Xiao-yi Liu and Y. Wang and Zhao-Chuan Yang and H. Xu and Hai-bo Wang},
  journal={Oncology reports},
  year={2013},
  volume={29 1},
  pages={
          219-25
        }
}
Metastasis is unequivocally the most lethal aspect of breast cancer and the most prominent feature associated with disease recurrence, the molecular mechanisms whereby epithelial-to-mesenchymal transition (EMT) mediates the initiation and resolution of breast cancer metastasis remains poorly understood. Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that is intimately involved in regulating numerous physiological… Expand
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