Transforming growth factor α expression in normal gastric mucosa, intestinal metaplasia, dysplasia and gastric carcinoma—an immunohistochemical study

@article{Nasim1992TransformingGF,
  title={Transforming growth factor $\alpha$ expression in normal gastric mucosa, intestinal metaplasia, dysplasia and gastric carcinoma—an immunohistochemical study},
  author={M. M. Nasim and D. M. Thomas and Malcolm R Alison and M. Isabel Filipe},
  journal={Histopathology},
  year={1992},
  volume={20}
}
Using a monoclonal antibody (GF10) and a standard immunohistochemical technique, immuno‐expression of transforming growth factor α (TGF‐α) was found consistently within the differentiated compartment of normal adult human gastric mucosa. In 70% of mucosal samples exhibiting intestinal metaplasia there was more or less uniform TGF‐α immunoreactivity throughout the intestinalized mucosa. Similarly, 60% of cases of dysplasia and 60% of gastric carcinomas showed strong immunoreactivity in most of… 
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