Transforming growth factor α expression in normal gastric mucosa, intestinal metaplasia, dysplasia and gastric carcinoma—an immunohistochemical study

@article{Nasim1992TransformingGF,
  title={Transforming growth factor $\alpha$ expression in normal gastric mucosa, intestinal metaplasia, dysplasia and gastric carcinoma—an immunohistochemical study},
  author={M. M. Nasim and D. M. Thomas and Malcolm R Alison and M. Isabel Filipe},
  journal={Histopathology},
  year={1992},
  volume={20}
}
Using a monoclonal antibody (GF10) and a standard immunohistochemical technique, immuno‐expression of transforming growth factor α (TGF‐α) was found consistently within the differentiated compartment of normal adult human gastric mucosa. In 70% of mucosal samples exhibiting intestinal metaplasia there was more or less uniform TGF‐α immunoreactivity throughout the intestinalized mucosa. Similarly, 60% of cases of dysplasia and 60% of gastric carcinomas showed strong immunoreactivity in most of… 
View on Wiley
26 Citations
Background Citations
5
Methods Citations
1
Results Citations
2

26 Citations

Transforming growth factor‐α immunoreactivity in a variety of epithelial tissues
TLDR
In all the epithelia studied there was a distinct spatial pattern of TGFα immunoreactivity, particularly in the continually renewing epithelium of the gastrointestinal tract and in the testis, where the spermatogonia were unstained, but the more luminally orientated germ cells were strongly positive.
Differential distribution of transforming growth factor-alpha immunohistochemistry within whole gastric mucosa in rats.
TLDR
Results show that parietal cells of rat gastric mucosa exhibit immunoreactivity to TGF-alpha, and its non-homogeneous distribution within different areas may be of importance in understanding the lesion pattern of gastric damage after the administration of noxious agents.
Role and new perspectives of transforming growth factor-α (TGF- α) in adenocarcinoma of the gastro-oesophageal junction
TLDR
Since TGF-α expression was associated with lymph node metastasis, its detection in preoperative perendoscopic biopsies might identify patients with more aggressive tumours who may need additional therapy, including neo-adjuvant treatment.
Immunohistochemical Studies on EGF Family Growth Factors in Normal and Ulcerated Human Gastric Mucosa
TLDR
In normal gastric mucosa, TGF-α, Cripto, and AR immunoreactivities were observed in thesurface epithelial and parietal cells of gastric fundicglands, respectively and the correlation between cellproliferation and EGFR was examined by double immunohistochemicalstaining for proliferating cell nuclear antigen (PCNA)and EGFR.
Transforming growth factor alpha disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice.
TLDR
It is shown that ectopically expressed TGF alpha induces an age-dependent cellular reorganization of the transgenic stomach, in which the surface mucous cell population in the gastric pit is greatly expanded at the expense of cells in the glandular base.
Transforming growth factor-alpha (TGF α)-producing gastric carcinoma with acanthosis nigricans: An endocrine effect of TGF α in the pathogenesis of cutaneous paraneoplastic syndrome and epithelial hyperplasia of the esophagus
TLDR
Evidence is concluded that large amounts of circulating TGF α in the blood over a long period released by the primary tumor seem to act as an endocrine-like mechanism causing epidermal and esophageal epithelial cells to proliferate.
Expression of transforming growth factor alpha in experimental gastric carcinogenesis.
TLDR
In experimental adenocarcinomas, a change to a previously undescribed pattern of perinuclear TGF alpha expression was found, which may represent the site of intense TGFalpha production in the Golgi apparatus after malignant transformation.
Assessment of proliferating cell nuclear antigen expression in precursor stages of gastric carcinoma using the PC10 antibody to PCNA
TLDR
Overall, increased PCNA indices, with expansion and altered location of the proliferative zones, were observed in carcinoma fields and compared with controls, and it is concluded that differences in PCNA index and staining patterns might prove useful in monitoring the evolution of the disease in the follow‐up of patients at risk of developing gastric cancer.
Gastric mucosal expression and luminal release of growth factors in gastric carcinoma and duodenal ulcer patients before and after eradication of Helicobacter pylori.
TLDR
It is indicated that overexpression of growth factors in gastric mucosa may be implicated in the pathogenesis of both duodenal ulcer and gastric cancer and that Hp positive hypochlorhydric and hypergastrinemic patients may be predisposed to development of Gastric cancer.
Regulation of terminal differentiation of zymogenic cells by transforming growth factor alpha in transgenic mice.
...
...

References

SHOWING 1-10 OF 57 REFERENCES
Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast
Expression of growth factor and epidermal growth factor receptor encoded transcripts in human gastric tissues.
TLDR
Coexpression of TGF alpha/EGFR supports the possibility of an autocrine loop sustaining tumor growth which is different from the mechanisms responsible for normal cellular proliferation.
Immunohistochemical study of epidermal growth factor and epidermal growth factor receptor in gastric carcinoma
TLDR
Results suggest that carcinomas in group 3 may have more proliferative and invasive activity and thus may have an autocrine mechanism, that is, the ability of cancer cells to produce and respond to their own growth factor.
Abnormal expression of growth regulatory factors in Barrett's oesophagus.
TLDR
Both normal gastric mucosa and Barrett's mucosa have potential autocrine growth regulatory mechanisms, but Barrett’s mucosa has increased expression of both of the measured ligands and of the epidermal growth factor receptor.
TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas
Transforming growth factor alpha and epidermal growth factor levels in normal human gastrointestinal mucosa.
TLDR
TGF alpha levels in extracts of gastrointestinal mucosa from a 7-year-old female donor were higher and the observed distribution was markedly different from adult levels, and URO-EGF was not detected in mucosal or submucosal tissue extracts from this patient.
Differential Expression of Transforming Growth Factors a and ft in Rat Intestinal Epithelial Cells
TLDR
TGF a and TGF 13 may play a significant role in the regulation of the balance between proliferative and differentiated cell compartments in the intestinal epithelium through both autocrine and paracrine mechanisms.
Differential expression of transforming growth factors alpha and beta in rat intestinal epithelial cells.
TLDR
TGF alpha and TGF beta may play a significant role in the regulation of the balance between proliferative and differentiated cell compartments in the intestinal epithelium through both autocrine and paracrine mechanisms.
Expression of the Transforming Growth Factor-α/Epidermal Growth Factor Receptor Pathway in Normal Human Breast Epithelial Cells
TLDR
A role for the TGF alpha/EGF receptor pathway in normal breast cell physiology is suggested and an autoregulatory autocrine loop appears operant in proliferating breast epithelial cells.
c‐erbB‐2 proto‐oncogene expression and its relationship to survival in gastric carcinoma: An immunohistochemical study on archival material
TLDR
Overall, patients with tumours expressing this proto‐oncogene had a significantly improved prognosis and within the group of intestinal‐type tumours, those that were c‐erbB‐2‐positive formed a distinct sub‐population which had a better prognosis, suggesting possible differences in aetiology.
...
...