Transforming growth factor-{beta}-inducible phosphorylation of Smad3.

  title={Transforming growth factor-\{beta\}-inducible phosphorylation of Smad3.},
  author={Guannan Wang and Isao Matsuura and Dongming He and Fang Liu},
  journal={The Journal of biological chemistry},
  volume={284 15},
Smad proteins transduce the transforming growth factor-beta (TGF-beta) signal at the cell surface into gene regulation in the nucleus. Upon TGF-beta treatment, the highly homologous Smad2 and Smad3 are phosphorylated by the TGF-beta receptor at the SSXS motif in the C-terminal tail. Here we show that in addition to the C-tail, three (S/T)-P sites in the Smad3 linker region, Ser(208), Ser(204), and Thr(179) are phosphorylated in response to TGF-beta. The linker phosphorylation peaks at 1 h after… CONTINUE READING
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