Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

@article{Der1982TransformingGO,
  title={Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.},
  author={Channing J Der and Theodore G. Krontiris and Geoffrey M. Cooper},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 11},
  pages={3637-40}
}
Blot hybridization analysis indicated that NIH 3T3 mouse bladder transformed by high molecular weight DNAs of a human bladder and a human lung carcinoma cell line contained new sequences homologous, respectively, to the transforming genes of Harvey (rasH) and Kirsten (rasK) sarcoma viruses. The unique ras sequences were present in multiple independent NIH cell lines transformed in both primary and secondary transfection assays and corresponded to ras sequences normally present in human DNAs… CONTINUE READING

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