Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands.

@article{Cortez2016TransformingGF,
  title={Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands.},
  author={Victor Cortez and Luisa Cervantes-Barragan and Michelle L Robinette and Jennifer K. Bando and Y Claire Wang and Theresa L. Geiger and Susan Gilfillan and Anja G. Fuchs and Eric Vivier and Joe C Sun and Marina Cella and Marco Colonna},
  journal={Immunity},
  year={2016},
  volume={44 5},
  pages={1127-39}
}
The signals guiding differentiation of innate lymphoid cells (ILCs) within tissues are not well understood. Salivary gland (SG) ILCs as well as liver and intestinal intraepithelial ILC1 have markers that denote tissue residency and transforming growth factor-β (TGF-β) imprinting. We deleted Tgfbr2 in cells expressing the ILC and NK marker NKp46 and found that SG ILCs were reduced in number. They lost distinct tissue markers, such as CD49a, and the effector molecules TRAIL and CD73. Expression… CONTINUE READING

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