Transforming Growth Factor-β Receptors and Smads: Regulatory Complexity and Functional Versatility.


Transforming growth factor (TGF)-β family proteins control cell physiology, proliferation, and growth, and direct cell differentiation, thus playing key roles in normal development and disease. The mechanisms of how TGF-β family ligands interact with heteromeric complexes of cell surface receptors to then activate Smad signaling that directs changes in gene… (More)
DOI: 10.1016/j.tcb.2017.04.005


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