Transforming Growth Factor-β: Activation by Neuraminidase and Role in Highly Pathogenic H5N1 Influenza Pathogenesis

  title={Transforming Growth Factor-β: Activation by Neuraminidase and Role in Highly Pathogenic H5N1 Influenza Pathogenesis},
  author={Christina Carlson and Elizabeth A. Turpin and Lindsey A. Moser and Kevin B. O'Brien and Troy D. Cline and Jeremy C. Jones and Terrence M. Tumpey and Jacqueline M. Katz and Laura A. Kelley and Jack Gauldie and Stacey T Schultz-Cherry},
  booktitle={PLoS pathogens},
Transforming growth factor-beta (TGF-β), a multifunctional cytokine regulating several immunologic processes, is expressed by virtually all cells as a biologically inactive molecule termed latent TGF-β (LTGF-β). We have previously shown that TGF-β activity increases during influenza virus infection in mice and suggested that the neuraminidase (NA) protein mediates this activation. In the current study, we determined the mechanism of activation of LTGF-β by NA from the influenza virus A/Gray… CONTINUE READING


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