Transforming Growth Factor / Smad 3 Signaling Regulates IRF-7 Function and Transcriptional Activation of the Beta Interferon Promoter

The rapid induction of alpha interferon (IFN) and IFNexpression plays a critical role in the innate immune response against viral infection. We studied the effects of transforming growth factor (TGF) and its intracellular effectors, the Smads, on the function of IRF-7, an essential transcription factor for IFNand induction. IRF-7 interacted with Smads, and… CONTINUE READING