Transforming Growth Factor‐β in Thoracic Aortic Aneurysms: Good, Bad, or Irrelevant?

Abstract

M arfan syndrome is a multisystem disorder, but its most devastating manifestations are aortic aneurysms and dissection. This syndrome results from mutations in FBN1, which encodes fibrillin-1, a microfibrillar protein that decorates the surface of elastin fibers. Over 100 known mutations in FBN1 cause Marfan syndrome, resulting in a wide variance of… (More)
DOI: 10.1161/JAHA.116.005221

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