Transformations of diphenylphosphinothioic acid tertiary amides mediated by directed ortho metallation.

Abstract

ortho-Lithiation of N,N-diisopropyl-P,P-diphenylphosphinothioic amide using n-BuLi in the presence of TMEDA in diethyl ether followed by electrophilic trapping is described as an efficient method for the synthesis of ortho-functionalised derivatives in high yields. The structural modification of the phosphinothioic amide includes C-X (X = P, S, Si, Sn, I… (More)
DOI: 10.1039/c2ob25395j

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