Transformations of N-Acyl-ε-caprolactams and the Synthesis of DL-Lysine

  title={Transformations of N-Acyl-$\epsilon$-caprolactams and the Synthesis of DL-Lysine},
  author={Roger J. Tull and R. C. O'neill and Edmund P. McCarthy and J J Pappas and John M. Chemerda},
  journal={Journal of Organic Chemistry},
A facile one pot route for the synthesis of imide tethered peptidomimetics.
The present method provides a convenient and easy access to imide tethered peptidomimetics and is compatible with common protecting groups employed in peptide chemistry.
In the crystal structure of the title compound, C13H14ClNO2, intermolecular C—H⋯O interactions link the molecules into a two-dimensional network.
Lactams X. Synthesis of derivatives of 9H-pyrimido [4, 5-b] azepine from caprolactam
By ethylation of 3-cyano- and 3-carboethoxycaprolactams with triethyloxonium fluoborate 3-cyano- and 3-carboethoxy-2-ethoxy-9H-3,4,5,6-tetrahydroazepines were obtained; by condensation with compounds
Studies on pyrrolidinones. Synthesis of N‐acylpyroglutamic esters with bactericide and fungicide properties
The best method to prepare N-acylpyroglutamic esters is to react N-trimethylsilylpyroglutamic esters with acid chlorides or diketene. These acylesters possess bactericide and fungicide properties
A Novel Transamidation
Abstract Reaction of N-benzoylcaprolactam (BCL) with sulfuryl chloride has been shown to produce N-benzoyl-α-chloro-∊-caprolactam (BCCL) in about 90% yield1 (reaction 1).
Steroids. Synthesis of 1,4-oxazine derivatives of estrone
Estratrieno[3,2-b]-1,4-oxazin-3′-one (V) and estratrieno[3,4-b]-1,4-oxazin-3′-one (VI) have been converted to the corresponding amidines. The tautomerism of the thiones and the amidines are discussed.