Transformation of sib-pair values for the Haseman-Elston method.

  title={Transformation of sib-pair values for the Haseman-Elston method.},
  author={Danxin Wang and Shili Lin and Rong Cheng and Xiaoyi Gao and Fred A. Wright},
  journal={American journal of human genetics},
  volume={68 5},
The squared sib-pair phenotype difference (SQD) has been used as a dependent variable in the Haseman-Elston (H-E) regression quantitative-trait locus (QTL) linkage method, but it has been shown that the SQD does not make full use of linkage information. In this study, we examine the efficiency of SQD in H-E regression compared to other proposed functions of the sib-pair phenotypes. A new function of sib-pair phenotypes, the product of pair values corrected with family mean (PCF), is shown to… CONTINUE READING

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