Transformation of human skeletal muscle cells by simian virus 40.

  title={Transformation of human skeletal muscle cells by simian virus 40.},
  author={Armand F. Miranda and Lee E. Babiss and Paul B Fisher},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={80 21},
Molecular studies of the biochemical alterations involved in human myopathies have been restricted because of the finite life-span and slow growth rate of cultures derived from primary tissue. Because the tumor virus simian virus 40 (SV40) can alter both the growth properties and longevity of human cells, we have infected skeletal muscle cultures derived from four biopsies with a small-plaque variant of SV40 and analyzed the biological and biochemical properties of cloned myoblast derivatives… CONTINUE READING
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