Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangement.

@article{Ouansafi2010TransformationOF,
  title={Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangement.},
  author={Ihsane Ouansafi and Bing He and Cory Fraser and Kui Nie and Susan Wndy Mathew and Rumina Bhanji and Rana S. Hoda and Melissa Arabadjief and Daniel M. Knowles and Andrea Cerutti and Attilio Orazi and Wayne Tam},
  journal={American journal of clinical pathology},
  year={2010},
  volume={134 6},
  pages={972-81}
}
Follicular lymphoma (FL) is an indolent lymphoma that transforms to high-grade lymphoma, mostly diffuse large B-cell lymphoma, in about a third of patients. We present the first report of a case of FL that transformed to plasmablastic lymphoma (PBL). Clonal transformation of the FL to PBL was evidenced by identical IGH/BCL2 gene rearrangements and VDJ gene usage in rearranged IGH genes. IGH/ BCL2 translocation was retained in the PBL, which also acquired c-myc gene rearrangement. Genealogic… CONTINUE READING
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