Transformation of follicular lymphoma into CD30-large cell lymphoma with anaplastic cytologic features.

@article{Alsabeh1997TransformationOF,
  title={Transformation of follicular lymphoma into CD30-large cell lymphoma with anaplastic cytologic features.},
  author={Randa Alsabeh and L Jeffrey Medeiros and Carlotta Glackin and Lawrence M. Weiss},
  journal={The American journal of surgical pathology},
  year={1997},
  volume={21 5},
  pages={528-36}
}
The natural history of follicular lymphoma is to accrue large cells and become diffuse, resulting in progression/transformation to a higher-grade lymphoma. Histologic transformation occurs in approximately 60% of patients. Most often, follicular lymphomas transform into diffuse large cell lymphoma, but transformation to lymphomas classified using the Working Formulation as diffuse mixed, large cell immunoblastic, or small noncleaved cell also have been reported. Evidence of transformation may… CONTINUE READING