Transformation of dopamine and alpha-methyldopamine by NG108-15 cells: formation of thiol adducts.

@article{Patel1991TransformationOD,
  title={Transformation of dopamine and alpha-methyldopamine by NG108-15 cells: formation of thiol adducts.},
  author={Nick Patel and Yoshito Kumagai and Steve E Unger and Jon M Fukuto and Arthur K. Cho},
  journal={Chemical research in toxicology},
  year={1991},
  volume={4 4},
  pages={421-6}
}
The catecholamines, alpha-methyldopamine (alpha-MeDA) and dopamine (DA), have been implicated in 3,4-(methylenedioxy)amphetamine (MDA) toxicity. The toxicity and metabolic fate of alpha-MeDA, a metabolite of MDA, and DA, a neurotransmitter released by MDA administration, were examined in NG108-15 cells. Both catechols were found to accumulate… CONTINUE READING