Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice

@article{Alkema1995TransformationOA,
  title={Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice},
  author={Mark J. Alkema and Nathalie M. T. van der Lugt and Ren{\'e} C. Bobeldijk and Anton Berns and Maarten van Lohuizen},
  journal={Nature},
  year={1995},
  volume={374},
  pages={724-727}
}
THE oncogene bmi-l, which was originally found to be involved in B- and T-cell lymphoma formation1–3 encodes a protein with a domain of homology to the Drosophila protein Posterior sex combs (Psc) and its relative Suppressor 2 of Zeste (Su(z)2) (refs 4 and 5). Psc is a member of the Poly comb-group gene family, which is required to maintain the repression of homeotic genes that regulate the identities of Drosophila segments6. The possibility that bmi-l may play a similar role in vertebrates was… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

Similar Papers

Loading similar papers…