Transformation of UV-hypersensitive Chinese hamster ovary cell mutants with UV-irradiated plasmids.

@article{Nairn1988TransformationOU,
  title={Transformation of UV-hypersensitive Chinese hamster ovary cell mutants with UV-irradiated plasmids.},
  author={Rodney S. Nairn and Ronald M. Humphrey and Gerald M. Adair},
  journal={International journal of radiation biology and related studies in physics, chemistry, and medicine},
  year={1988},
  volume={53 2},
  pages={249-60}
}
Transfection of UV-hypersensitive, DNA repair-deficient Chinese hamster ovary (CHO) cell lines and parental, repair-proficient CHO cells with UV-irradiated pHaprt-1 or pSV2gpt plasmids resulted in different responses by recipient cell lines to UV damage in transfected DNA. Unlike results that have been reported for human cells, UV irradiation of transfecting DNA did not stimulate the genetic transformation of CHO recipient cells. In repair-deficient CHO cells, proportionally fewer transformants… CONTINUE READING

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