Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus.

@article{Baichwal1988TransformationOB,
  title={Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus.},
  author={Vijay R. Baichwal and Bill Sugden},
  journal={Oncogene},
  year={1988},
  volume={2 5},
  pages={461-7}
}
The BNLF-1 protein is the only non-nuclear Epstein-Barr virus (EBV) encoded protein that has been detected in B-lymphocytes immortalized by EBV. We demonstrate that the BNLF-1 gene induces anchorage-independent growth and tumorigenic transformation of the murine cell-line, Balb/3T3. This demonstration extends the earlier observation that the BNLF-1 gene can transform Rat-1 cells. In addition we find that the BNLF-1 protein is located in the particulate fraction of cells, is phosphorylated, and… CONTINUE READING

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