Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling

@article{Deangelis2006TransformationBT,
  title={Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling},
  author={Tiziana Deangelis and J Chen and An Jan Wu and Marco Prisco and Renato Baserga},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={32-42}
}
Previous work has shown that the Simian Virus 40 T antigen (T antigen) cannot transform mouse embryo fibroblasts (MEFs) that do not express the type 1 insulin-like growth factor receptor (IGF-IR). We have now investigated the mechanism(s) by which the transforming activity of T antigen is affected by IGF-IR signaling. We demonstrate that transformation by T antigen of MEFs and several other cell lines requires an insulin receptor substrate-1 (IRS-1) phosphorylated on tyrosines. If IRS-1 is not… CONTINUE READING
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