Transformation by ras suppresses expression of the neurotrophic growth factor pleiotrophin.

Abstract

An 18-kDa protein (p18) was detected in lysates and conditioned medium from contact-arrested NIH 3T3 fibroblasts, but was not detected when the cells were transformed by the oncogene ras. Analysis of transformation-defective cell clones generated after mutagenesis of the ras-retroviral vector used to transduce the ras gene showed an inverse correlation… (More)

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@article{Corbley1997TransformationBR, title={Transformation by ras suppresses expression of the neurotrophic growth factor pleiotrophin.}, author={Michael J. Corbley}, journal={The Journal of biological chemistry}, year={1997}, volume={272 39}, pages={24696-702} }