Transformation by polyoma virus middle T antigen.

  title={Transformation by polyoma virus middle T antigen.},
  author={Sara A Courtneidge},
  journal={Cancer surveys},
  volume={5 2},
The transforming protein of polyoma virus, middle T antigen, is a membrane-associated phosphoprotein. Middle T forms a complex with, and is phosphorylated by, a cellular tyrosine kinase pp60c-src. Mutant analysis suggests that formation of this complex is critical to transformation by polyoma. Middle T binding causes pp60c-src to autophosphorylate at novel sites in its amino terminus, and increases the specific activity of the enzyme. However, at least one non-transforming mutant of middle T… CONTINUE READING