Transformation by Wnt family proteins correlates with regulation of beta-catenin.

  title={Transformation by Wnt family proteins correlates with regulation of beta-catenin.},
  author={Hideo Shimizu and M. D. Demetrios A. Julius and Marianna Giarr{\`e} and Zhili Zheng and Anthony M. C. Brown and Jan Kitajewski},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  volume={8 12},
Several members of the Wnt family of secreted factors are strongly implicated as regulators of mammary cell growth and differentiation. To investigate Wnt signaling in mammary cells, we have assessed the abilities of 10 different Wnt genes to cause transformation of C57MG mammary epithelial cells and in parallel studied their effects on beta-catenin, a component of the Wnt-1 signaling pathway. Autocrine transforming potential was tested by expression of Wnt proteins in C57MG cells, and… CONTINUE READING
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