Transformation and normalization of oligonucleotide microarray data

@article{Geller2003TransformationAN,
  title={Transformation and normalization of oligonucleotide microarray data},
  author={Sue C. Geller and Jeff P. Gregg and Paul Hagerman and David M. Rocke},
  journal={Bioinformatics},
  year={2003},
  volume={19 14},
  pages={1817-23}
}
MOTIVATION Most methods of analyzing microarray data or doing power calculations have an underlying assumption of constant variance across all levels of gene expression. The most common transformation, the logarithm, results in data that have constant variance at high levels but not at low levels. Rocke and Durbin showed that data from spotted arrays fit a two-component model and Durbin, Hardin, Hawkins, and Rocke, Huber et al. and Munson provided a transformation that stabilizes the variance… CONTINUE READING
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