Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1.

  title={Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1.},
  author={Teresa M. Calonge and Majid Eshaghi and Jianhua Liu and Ze'ev A Ronai and Matthew J O'Connell},
  volume={185 1},
The G2 DNA damage checkpoint inhibits Cdc2 and mitotic entry through the dual regulation of Wee1 and Cdc25 by the Chk1 effector kinase. Upregulation of Chk1 by mutation or overexpression bypasses the requirement for upstream regulators or DNA damage to promote a G2 cell cycle arrest. We screened in fission yeast for mutations that rendered cells resistant to overexpressed chk1(+). We identified a mutation in tra1, which encodes one of two homologs of transformation/transcription domain… CONTINUE READING


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