Transfersomal lyophilized gel of buspirone HCl: formulation, evaluation and statistical optimization.

@article{Shamma2013TransfersomalLG,
  title={Transfersomal lyophilized gel of buspirone HCl: formulation, evaluation and statistical optimization.},
  author={Rehab Nabil Shamma and Ibrahim Elsayed},
  journal={Journal of liposome research},
  year={2013},
  volume={23 3},
  pages={244-54}
}
CONTEXT Buspirone HCl has very low oral bioavailability (4%) due to deactivation by extensive first pass effect. It also has very limited transdermal permeation due to its high hydrophilicity. OBJECTIVE The aim of this study was to increase the transdermal permeation of buspirone HCl utilizing a stable dosage form. METHODS Transfersomes were prepared using Tween-80 as a flexibility imparting agent to the vesicular walls. Oleic acid and/or ethanol, with different percentages, were utilized… CONTINUE READING

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