Transferring the C-terminus of the chemokine CCL21 to CCL19 confers enhanced heparin binding.

  title={Transferring the C-terminus of the chemokine CCL21 to CCL19 confers enhanced heparin binding.},
  author={Austin J Barmore and Sally M Castex and Brittany A Gouletas and Alex J Griffith and Slater W Metz and Nicolas G Muelder and Michael J Populin and David M Sackett and Abigail M Schuster and Christopher T. Veldkamp},
  journal={Biochemical and biophysical research communications},
  volume={477 4},
Chemokines direct the migration of cells during various immune processes and are involved in many disease states. For example, CCL19 and CCL21, through activation of the CCR7 receptor, recruit dendritic cells and naïve T-cells to the secondary lymphoid organs aiding in balancing immune response and tolerance. However, CCL19 and CCL21 can also direct the metastasis of CCR7 expressing cancers. Chemokine binding to glycosaminoglycans, such as heparin, is as important to chemokine function as… CONTINUE READING
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