Transferrin synthesis is increased in nephrotic patients insufficiently to replace urinary losses.

  title={Transferrin synthesis is increased in nephrotic patients insufficiently to replace urinary losses.},
  author={Berthil H C M T Prinsen and Monique G. M. de Sain-van der Velden and George Alan Kaysen and Helma W H C Straver and Herman J M van Rijn and Frans Stellaard and R. G. Berger and Ton J Rabelink},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={12 5},
The urinary loss of transferrin is sufficient to reduce plasma transferrin concentrations in the nephrotic syndrome. Hypotransferrinemia may lead to iron loss and microcytic anemia. The mechanism responsible for the hypotransferrinemia in the nephrotic syndrome is, however, unknown. In the present study, synthesis rate of transferrin was measured in vivo in nephrotic patients (n = 7) compared with control subjects (n = 6) using L-[1-(13)C]-valine. Plasma transferrin and iron concentration in… CONTINUE READING

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al-Bander H: Non-iron mediated alteration in hepatic transferrin gene expression in the nephrotic rat

  • GA Kaysen, X Sun, +4 authors WG Couser
  • Kidney Int
  • 1995
Highly Influential
7 Excerpts

Chronic protein deficiency differentially affects the 1024 Journal of the American Society of Nephrology

  • F Jahoor, S Bhattiprolu, M Del Rosario, D Burrin, L Wykes, M Frazer
  • J Am Soc Nephrol
  • 2001
1 Excerpt

Total body protein synthesis does not increase despite increased synthesis and urinary losses of liver derived protein in the nephrotic syndrome

  • MG de Sain-van der Velden, K de Meer, +4 authors GA Kaysen
  • Am J Kidney Dis
  • 2000
1 Excerpt

Koomans HA: Proportionate increase of fibrinogen and albumin synthesis in nephrotic patients: Measurements with stable isotopes

  • MG De Sain-van der Velden, GA Kaysen, +4 authors TJ Rabelink
  • Kidney Int
  • 1998
11 Excerpts

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