Transferrin synthesis is increased in nephrotic patients insufficiently to replace urinary losses.

@article{Prinsen2001TransferrinSI,
  title={Transferrin synthesis is increased in nephrotic patients insufficiently to replace urinary losses.},
  author={Berthil H C M T Prinsen and Monique G. M. de Sain-van der Velden and George Alan Kaysen and Helma W H C Straver and Herman J M van Rijn and Frans Stellaard and R. G. Berger and Ton J Rabelink},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2001},
  volume={12 5},
  pages={1017-25}
}
The urinary loss of transferrin is sufficient to reduce plasma transferrin concentrations in the nephrotic syndrome. Hypotransferrinemia may lead to iron loss and microcytic anemia. The mechanism responsible for the hypotransferrinemia in the nephrotic syndrome is, however, unknown. In the present study, synthesis rate of transferrin was measured in vivo in nephrotic patients (n = 7) compared with control subjects (n = 6) using L-[1-(13)C]-valine. Plasma transferrin and iron concentration in… CONTINUE READING

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