Transferrin receptors in rat brain: neuropeptide-like pattern and relationship to iron distribution.

@article{Hill1985TransferrinRI,
  title={Transferrin receptors in rat brain: neuropeptide-like pattern and relationship to iron distribution.},
  author={Joanna M. Hill and Michael Ruff and Richard J. Weber and Candace B. Pert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 13},
  pages={4553-7}
}
We have characterized and visualized the binding of 125I-labeled transferrin to sections of rat brain. This saturable, reversible, high-affinity (Kd = 1 X 10(-9) M) binding site appears indistinguishable from transferrin receptors previously characterized in other tissues. Moreover, a monoclonal antibody raised to rat lymphocyte transferrin receptors could immunoprecipitate recovered intact transferrin solubilized from labeled brain slices, indicating that labeling was to the same molecular… CONTINUE READING

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