Transferrin receptor recycling in rat hepatocytes is regulated by protein phosphatase 2A, possibly through effects on microtubule-dependent transport.

@article{Runnegar1997TransferrinRR,
  title={Transferrin receptor recycling in rat hepatocytes is regulated by protein phosphatase 2A, possibly through effects on microtubule-dependent transport.},
  author={Maria T. C. Runnegar and Xiangyang Wei and N Berndt and Sarah F Hamm-Alvarez},
  journal={Hepatology},
  year={1997},
  volume={26 1},
  pages={176-85}
}
To understand the regulation of receptor-mediated endocytosis in hepatocytes, we have used two specific inhibitors of serine-threonine protein phosphatases (PP), microcystin (MCYST) and okadaic acid (OKA) as probes to alter protein phosphorylation in hepatocytes. We have then examined the impact of these changes on the specific binding and uptake of transferrin (Tf) in hepatocytes. The measurement of PP activity in hepatocyte lysates showed that OKA and MCYST shared a common inhibition of… CONTINUE READING
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