Transferrin receptor distribution and iron deposition in the hepatic fobufe of iron‐overloaded rats

  title={Transferrin receptor distribution and iron deposition in the hepatic fobufe of iron‐overloaded rats},
  author={J P Lu and K. Hayashi},
  journal={Pathology International},
  • J. Lu, K. Hayashi
  • Published 1 March 1995
  • Biology, Medicine
  • Pathology International
Under the condition of obvious iron‐overload, there is a zonal hernoeiderin (iron) deposition in hepatic lobules. The deposition is heavtest in the periporfal (zone 1) and lightest in the perivenws (zone 3) hepatocytes. However, the mechanism for this pattern of iron deposition is obscure. Hepatic tissues from control, iron‐deficlent or ironoverloaded Wistar rats me used to study its pathogenesis. iron‐deficiency was Induced by a low Iron regimen. Ironoverload was produced by repeated… 
Topographic Relation Between Iron-Deposition and Cytotoxic Changes in Iron Lactate-Overloaded Rats
Main histopathologic changes were an accumulation of excess iron in the hepatocytes, renal tubular epithelial cells, macrophages in the reticuloendothelial system of liver, spleen, bone marrow, and lymph nodes, and a slight elevation of AST, ALT, creatinine, and blood urea nitrogen levels suggested the toxic effect of iron overload on the function of liver and kidneys.
Dietary Iron Overload Differentially Modulates Chemically-Induced Liver Injury in Rats
It is suggested that susceptibility to drugs or chemical compounds can be differentially altered in iron-overloaded livers through enhanced oxidative stress while it attenuates CCl4-induced Zone-3 liver injury, partly via the suppression of apoptosis pathway.
Duodenal absorption and tissue utilization of dietary heme and nonheme iron differ in rats.
Differential tissue utilization of heme vs. nonheme iron was evident between erythroid and iron storage tissues, suggesting that some heme may be exported into the circulation in a form different from that of non heme iron.
Involvement of cytosolic and mitochondrial iron in iron overload cardiomyopathy: an update
The mechanisms of cytosolic and/or mitochondrial iron load in the heart which may contribute synergistically or independently to the development of iron-associated cardiomyopathy are reviewed.
Coincident increase in periportal expression of iron proteins in the iron‐loaded rat liver
The liver is the major iron storage organ in the body and total body iron stores closely regulate hepatocyte iron uptake, storage and release, and transferrin, transferrin receptor and ferritin facilitate these processes.
Estudos bioquímicos e hematológicos em ratos sobre biodisponibilidade de minerais numa dieta enriquecida com multimistura
The addition of multimistura to the creche diet, even in double quantities, did not affect the seric concentrations of minerals analysed and the analysis of blood red cells showed that groups presented values in the limits of normality.
Relationship Between Serum Iron Profile and Liver Density in Non-Enhanced CT-Scan
The evaluation of liver density may be an alternative to liver biopsy in some cases or at least can be considered to restrict unnecessary biopsies, and there was no relationship between serum iron levels and serum ferritin with the difference between liver and spleen density.
In situ detection of TGF betas, TGF beta receptor II mRNA and telomerase activity in rat cholangiocarcinogenesis.
There were TGFbetas, TbetaRII expression and telomerase activity in hyperplastic, dysplastic cholangiocytes, cholANGiocarcinoma cells as well as in stroma fibroblasts during cholangsiocARCinogenesis.


Transferrin Receptor Expression in Normal, Iron‐deficient and Iron‐overloaded Rats
It is concluded that TfR expression is negatively regulated by the tissue concentration of iron.
Transferrin Receptors and Selective Iron Deposition in Pancreatic B Cells of Iron‐overloaded Rats
Iron overload was produced in Wistar rats by repeated intraperitoneal injections of ferric nitrilotriacetate (Fe3+‐NTA) for one to six months and findings suggest that iron uptake by islet cells in vivo is regulated and mediated by TfR.
Lack of hepatic transferrin receptor expression in hemochromatosis
It is shown that in advanced hemochromatosis hepatocytes do not express transferrin receptors, in keeping with the inverse relation between transferrin receptor expression and exogenous iron supply in various cell cultures.
Iron and the liver.
  • H. Bonkovsky
  • Medicine, Biology
    The American journal of the medical sciences
  • 1991
Vigorous efforts at diagnosis and treatment of iron overload are essential since the pathologic effects of iron are totally preventable by early vigorous iron removal and prevention of iron re-accumulation.
Transferrin receptor expression in rat liver: Immunohistochemical and biochemical analysis of the effect of age and iron storage
Findings support down‐regulation of parenchymal transferrin receptor resulting from iron storage, however, the positivity of siderotic reticuloendothelial cells and the absence of reemergence of pournachymal receptors in conditions of minimal paren chymal and prominent reticulum siderosis need further elucidation.
The Role of Iron in the Regulation of Hepatic Transferrin Synthesis
The role of iron supply in the regulation of hepatic transferrin synthesis by the isolated perfused rat liver was studied using nutritional iron deficiency as the experimental model and the concentration of liver iron stores appears to be a major regulatory factor in the control of hepato-transferrin synthesis.
Effect of cellular iron concentration on iron uptake by hepatocytes.
Results indicated that, in cultured hepatocytes, transferrin receptor expression and the subsequent uptake of transferrin and iron are regulated by the size of an intracellular, chelatable iron pool, whereas the uptake of iron by the nonsaturable processes is dependent on the extracellular transferrin concentration.
Selective iron deposition in pancreatic islet B cells of transfusional iron‐overloaded autopsy cases
Immunohistochemical and histo‐chemical stainings were used to clarify the relationship between blood transfusion and iron deposition in the islet and in severely iron‐overloaded cases, hemosiderin was selectively deposited in B cells of the islets.
Induction of diabetes in animals by parenteral administration of ferric nitrilotriacetate. A model of experimental hemochromatosis.
Repeated blood withdrawals from ferric-nitrilotriacetate-treated animals resulted in disappearance of hypergycmia, glycosuria, ketonemia, and ketonuria; disappearance of iron from the liver and pancreas; and restoration of islet beta granules to the control level.