Transferrin receptor distribution and iron deposition in the hepatic fobufe of iron‐overloaded rats

@article{Lu1995TransferrinRD,
  title={Transferrin receptor distribution and iron deposition in the hepatic fobufe of iron‐overloaded rats},
  author={J P Lu and K. Hayashi},
  journal={Pathology International},
  year={1995},
  volume={45}
}
  • J. Lu, K. Hayashi
  • Published 1 March 1995
  • Biology, Medicine
  • Pathology International
Under the condition of obvious iron‐overload, there is a zonal hernoeiderin (iron) deposition in hepatic lobules. The deposition is heavtest in the periporfal (zone 1) and lightest in the perivenws (zone 3) hepatocytes. However, the mechanism for this pattern of iron deposition is obscure. Hepatic tissues from control, iron‐deficlent or ironoverloaded Wistar rats me used to study its pathogenesis. iron‐deficiency was Induced by a low Iron regimen. Ironoverload was produced by repeated… 
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References

SHOWING 1-10 OF 36 REFERENCES
Transferrin Receptor Expression in Normal, Iron‐deficient and Iron‐overloaded Rats
TLDR
It is concluded that TfR expression is negatively regulated by the tissue concentration of iron.
Transferrin Receptors and Selective Iron Deposition in Pancreatic B Cells of Iron‐overloaded Rats
TLDR
Iron overload was produced in Wistar rats by repeated intraperitoneal injections of ferric nitrilotriacetate (Fe3+‐NTA) for one to six months and findings suggest that iron uptake by islet cells in vivo is regulated and mediated by TfR.
Lack of hepatic transferrin receptor expression in hemochromatosis
TLDR
It is shown that in advanced hemochromatosis hepatocytes do not express transferrin receptors, in keeping with the inverse relation between transferrin receptor expression and exogenous iron supply in various cell cultures.
Iron and the liver.
  • H. Bonkovsky
  • Medicine, Biology
    The American journal of the medical sciences
  • 1991
TLDR
Vigorous efforts at diagnosis and treatment of iron overload are essential since the pathologic effects of iron are totally preventable by early vigorous iron removal and prevention of iron re-accumulation.
Transferrin receptor expression in rat liver: Immunohistochemical and biochemical analysis of the effect of age and iron storage
TLDR
Findings support down‐regulation of parenchymal transferrin receptor resulting from iron storage, however, the positivity of siderotic reticuloendothelial cells and the absence of reemergence of pournachymal receptors in conditions of minimal paren chymal and prominent reticulum siderosis need further elucidation.
The Role of Iron in the Regulation of Hepatic Transferrin Synthesis
TLDR
The role of iron supply in the regulation of hepatic transferrin synthesis by the isolated perfused rat liver was studied using nutritional iron deficiency as the experimental model and the concentration of liver iron stores appears to be a major regulatory factor in the control of hepato-transferrin synthesis.
Effect of cellular iron concentration on iron uptake by hepatocytes.
TLDR
Results indicated that, in cultured hepatocytes, transferrin receptor expression and the subsequent uptake of transferrin and iron are regulated by the size of an intracellular, chelatable iron pool, whereas the uptake of iron by the nonsaturable processes is dependent on the extracellular transferrin concentration.
Selective iron deposition in pancreatic islet B cells of transfusional iron‐overloaded autopsy cases
TLDR
Immunohistochemical and histo‐chemical stainings were used to clarify the relationship between blood transfusion and iron deposition in the islet and in severely iron‐overloaded cases, hemosiderin was selectively deposited in B cells of the islets.
Induction of diabetes in animals by parenteral administration of ferric nitrilotriacetate. A model of experimental hemochromatosis.
TLDR
Repeated blood withdrawals from ferric-nitrilotriacetate-treated animals resulted in disappearance of hypergycmia, glycosuria, ketonemia, and ketonuria; disappearance of iron from the liver and pancreas; and restoration of islet beta granules to the control level.
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