Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells.

@article{Wagner1991TransferrinpolycationDNACT,
  title={Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells.},
  author={E Wagner and M L Cotten and Roland Foisner and Max L. Birnstiel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 10},
  pages={4255-9}
}
We have previously described a gene delivery system based upon the receptor-mediated endocytosis of DNA complexed with transferrin-polycation conjugates. This delivery system has been found to be very effective for both the internalization and the expression of genetic material in cells that have many transferrin receptors. Upon scrutinization of the parameters involved in this method, which we have termed transferrinfection, we note two important features of the process: the polycation in… CONTINUE READING

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