Transferrin mediated solid lipid nanoparticles containing curcumin: enhanced in vitro anticancer activity by induction of apoptosis.

@article{Mulik2010TransferrinMS,
  title={Transferrin mediated solid lipid nanoparticles containing curcumin: enhanced in vitro anticancer activity by induction of apoptosis.},
  author={R. S. Mulik and Jukka M{\"o}nkk{\"o}nen and Risto O Juvonen and Kakasaheb Ramoo Mahadik and Anant Paradkar},
  journal={International journal of pharmaceutics},
  year={2010},
  volume={398 1-2},
  pages={190-203}
}
Photodegradation and low bioavailability are major hurdles for the therapeutic use of curcumin. Aim of the present study was to formulate transferrin-mediated solid lipid nanoparticles (Tf-C-SLN) to increase photostability, and enhance its anticancer activity against MCF-7 breast cancer cells. Tf-C-SLN were prepared by homogenization method and characterized by size, zeta potential, entrapment efficiency and stability, transmission electron microscopy (TEM), X-ray diffraction (XRD) and in vitro… CONTINUE READING

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