Transferrin inhibits stress-induced apoptosis in a beetle.

  title={Transferrin inhibits stress-induced apoptosis in a beetle.},
  author={Kwang Sik Lee and Bo Yeon Kim and Hong Ja Kim and Sook Jae Seo and Hyung Joo Yoon and Yong‐Soo Choi and Iksoo Kim and Yeon Soo Han and Yeon Ho Je and Sang Mong Lee and Doh Hoon Kim and Hung Dae Sohn and Byung Rae Jin},
  journal={Free radical biology \& medicine},
  volume={41 7},

Insect transferrin functions as an antioxidant protein in a beetle larva.

  • Bo Yeon KimK. Lee B. Jin
  • Biology
    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
  • 2008

Role for Transferrin in Triggering Apoptosis in Helicoverpa armigera Cells Treated with 2-Tridecanone.

It is found that HaTrf mediates the inhibition of apoptotic cell death during exposure to 2-tridecanone and provides insight into the importance of transferrin in the interaction between plants and insects.

Transcriptional profiling of transferrin gene from Egyptian cotton leaf worm, Spodoptera littoralis

While SpliTrf expression is upregulated upon bacterial infection, it is downregulated upon baculoviral infection and the role of transferrin in iron metabolism as well as in host immune physiology is discussed.

Functional disruption of transferrin expression alters reproductive physiology in Anopheles culicifacies

Iron supplementation and dsRNA mediated knockdown experiments together confer that AcTrf1a may have key role in the iron homeostasis regulation during oogenesis, and egg maturation in the gravid female mosquitoes.

Differential regulation of transferrin 1 and 2 in Aedes aegypti.

Dynamics of Transferrin 2 (Tsf2) Expression in Various Developmental Stages of Culex quinquefasciatus

An elevation in the fold change expression of Tsf2 in the larval to pupal stages followed by a decline in the folds of the adult stage is observed, suggesting that the upregulation may be because of the microbial challenge or the aquatic stages are programmed to synthesis moreTsf2 to encounter the upcoming microbes present in the aquatic environment.

Expression profile of the iron-binding proteins transferrin and ferritin heavy chain subunit in the bumblebee Bombus ignitus.

  • Bo Yeon KimK. Lee B. Jin
  • Biology
    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
  • 2009



Insects, oxygen, and iron.

  • J. H. Law
  • Biology
    Biochemical and biophysical research communications
  • 2002
In insect transferrins, unlike those of any other group of organisms, are exported into the extracellular space (hemolymph) and may be involved in iron transport and/or protection against iron overload in the diet.

Insect iron binding proteins: insights from the genomes.

Isolation and characterization of a termite transferrin gene up‐regulated on infection

No widespread evidence for pathogen‐mediated positive selection was detected at this locus, unlike certain vertebrate transferrin lineages, and codon‐based tests for selection among known insect transferrins revealed only a small proportion of cod on‐sites positively selected.

Mosquito transferrin, an acute-phase protein that is up-regulated upon infection.

The hypothesis is developed that this transferrin plays a role similar to vertebrate lactoferrin in sequestering iron from invading organisms and that degradation of the structure of the C-terminal lobe might be a mechanism for evading pathogens that elaborate transferrin receptors to tap sequestered iron.

Aedes aegypti transferrin. Gene structure, expression pattern, and regulation

Mosquitoes and all other insects so far examined have an abundant haemolymph transferrin (Tsf) proteins, which may be involved in iron transport, in oogenesis and in innate immune defence against parasites and pathogens.

Effects of heat shock, stannous chloride, and gallium nitrate on the rat inflammatory response

Tissue levels of inducible Hsp70 were detected in aortic tissues from heat- and stannous chloride–treated animals, indicating that these tissues were in a cytoprotected state that was also an anti-inflammatory state.

Transferrin in a cockroach: molecular cloning, characterization, and suppression by juvenile hormone.

The cDNA representing a message that was strongly suppressed by juvenile hormone in the fat body of the cockroach Blaberus discoidalis showed compelling resemblance in sequence to the transferrins, a superfamily of internally duplicated, 80-kDa iron-binding/transport proteins characterized from several vertebrates and one insect.