Transferrin conjugates of doxorubicin: synthesis, characterization, cellular uptake, and in vitro efficacy.

@article{Kratz1998TransferrinCO,
  title={Transferrin conjugates of doxorubicin: synthesis, characterization, cellular uptake, and in vitro efficacy.},
  author={Felix Kratz and Ulrich Beyer and Thomas F. Roth and Nadya Tarasova and Philippe Collery and Frederic Lechenault and A. Cazabat and Petra Schumacher and Clemens Unger and U Falken},
  journal={Journal of pharmaceutical sciences},
  year={1998},
  volume={87 3},
  pages={338-46}
}
One strategy for improving the antitumor selectivity and toxicity profile of antitumor agents is to design drug carrier systems employing suitable carrier proteins. Thus, thiolated human serum transferrin was conjugated with four maleimide derivatives of doxorubicin that differed in the stability of the chemical link between drug and spacer. Of the maleimide derivatives, 3-maleimidobenzoic or 4-maleimidophenylacetic acid was bound to the 3'-amino position of doxorubicin through a benzoyl or… CONTINUE READING
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