Transferrin binds insulin‐like growth factors and affects binding properties of insulin‐like growth factor binding protein‐3

@article{Storch2001TransferrinBI,
  title={Transferrin binds insulin‐like growth factors and affects binding properties of insulin‐like growth factor binding protein‐3},
  author={S. Storch and B. K{\"u}bler and S. H{\"o}ning and M. Ackmann and J. Zapf and W. Blum and T. Braulke},
  journal={FEBS Letters},
  year={2001},
  volume={509}
}
In the circulation, most of the insulin‐like growth factors (IGFs) are bound to a ternary 150 kDa complex with IGF‐binding protein (IGFBP)‐3 and the acid labile subunit. In the current study, we identify transferrin (Tf) by mass spectrometry, and immunoprecipitation as a component of a major IGF‐binding fraction separated from human plasma. IGF ligand blotting, cross‐linkage experiments and surface plasmon resonance spectrometry have been used to demonstrate the capability of Tf to bind IGFs… Expand
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  • 149
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  • 139
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References

SHOWING 1-10 OF 18 REFERENCES
Transferrin is an insulin-like growth factor-binding protein-3 binding protein.
  • 116
  • PDF
Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3.
  • 46
Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities.
  • R. Baxter
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
  • 2000
  • 606
  • PDF
Insulin-like Growth Factor-binding Protein-3 Binds Fibrinogen and Fibrin*
  • 93
  • PDF
The insulin-like growth factor-binding protein (IGFBP) superfamily.
  • 993
  • PDF
...
1
2
...