Transferrin binds insulin‐like growth factors and affects binding properties of insulin‐like growth factor binding protein‐3

  title={Transferrin binds insulin‐like growth factors and affects binding properties of insulin‐like growth factor binding protein‐3},
  author={S. Storch and B. K{\"u}bler and S. H{\"o}ning and M. Ackmann and J. Zapf and W. Blum and T. Braulke},
  journal={FEBS Letters},
In the circulation, most of the insulin‐like growth factors (IGFs) are bound to a ternary 150 kDa complex with IGF‐binding protein (IGFBP)‐3 and the acid labile subunit. In the current study, we identify transferrin (Tf) by mass spectrometry, and immunoprecipitation as a component of a major IGF‐binding fraction separated from human plasma. IGF ligand blotting, cross‐linkage experiments and surface plasmon resonance spectrometry have been used to demonstrate the capability of Tf to bind IGFs… Expand
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