Transferrin-bearing polypropylenimine dendrimer for targeted gene delivery to the brain.

Abstract

The possibility of using genes as medicines to treat brain diseases is currently limited by the lack of safe and efficacious delivery systems able to cross the blood-brain barrier, thus resulting in a failure to reach the brain after intravenous administration. On the basis that iron can effectively reach the brain by using transferrin receptors for… (More)
DOI: 10.1016/j.jconrel.2014.06.006

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