Transferrin and transferrin receptors update

@article{Kawabata2019TransferrinAT,
  title={Transferrin and transferrin receptors update},
  author={Hiroshi Kawabata},
  journal={Free Radical Biology and Medicine},
  year={2019},
  volume={133},
  pages={46–54}
}
  • H. Kawabata
  • Published 2019
  • Chemistry, Medicine
  • Free Radical Biology and Medicine
ABSTRACT In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells. Tf‐bound iron is incorporated through Tf receptor (TfR) 1‐mediated endocytosis. TfR1 can mediate cellular uptake of both Tf and H‐ferritin, an iron storage protein. New World arenaviruses, which cause hemorrhagic fever, and Plasmodium vivax use TfR1 for entry into host cells. Human TfR2, another receptor for Tf, is predominantly expressed in hepatocytes and erythroid precursors, and holo‐Tf dramatically… Expand
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