Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions.

@article{Loeffler1995TransferrinAI,
  title={Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions.},
  author={David A. Loeffler and James R. Connor and Paul L. Juneau and Brian S. Snyder and L Kanaley and A J Demaggio and H U Nguyen and Chaim M. Brickman and Peter A Lewitt},
  journal={Journal of neurochemistry},
  year={1995},
  volume={65 2},
  pages={710-24}
}
Oxidant-mediated damage is suspected to be involved in the pathogenesis of several neurodegenerative disorders. Iron promotes conversion of hydrogen peroxide to hydroxyl radical and, thus, may contribute to oxidant stress. We measured iron and its transport protein transferrin in caudate, putamen, globus pallidus, substantia nigra, and frontal cortex of subjects with Alzheimer's disease (n = 14) and Parkinson's disease (n = 14), and in younger adult (n = 8) and elderly (n = 8) normal controls… CONTINUE READING
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