Transferrin Receptor Polarity and Recycling Accuracy in " Tight " and " Leaky " Strains of Madin-Darby Canine Kidney Cells

@inproceedings{Ful2002TransferrinRP,
  title={Transferrin Receptor Polarity and Recycling Accuracy in " Tight " and " Leaky " Strains of Madin-Darby Canine Kidney Cells},
  author={Stephen D. Ful},
  year={2002}
}
  • Stephen D. Ful
  • Published 2002
We have characterized the polarity of the transferrin receptor in the epithelial Madin-Darby canine kidney (MDCK) cell line. The receptor is present in ~165,000 copies per cell, migrates as a diffuse band upon SDS gel electrophoresis with Mr 90,000, displays a dissociation constant for diferritransferrin at neutral pH of ~ 2 nM, and is active in essentially all of the cells of the population. Transferrin-mediated 55Fe uptake was used to measure the polarity of active transferrin receptors in… CONTINUE READING

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