Transferrin-Modified Nanoparticles for Photodynamic Therapy Enhance the Antitumor Efficacy of Hypocrellin A

@inproceedings{Lin2017TransferrinModifiedNF,
  title={Transferrin-Modified Nanoparticles for Photodynamic Therapy Enhance the Antitumor Efficacy of Hypocrellin A},
  author={Xi Lin and Shu-Zhen Yan and Shan-Shan Qi and Qiao Xu and Shuang-shuang Han and Ling-Yuan Guo and Ning Zhao and Shuang-lin Chen and Shu-Qin Yu},
  booktitle={Front. Pharmacol.},
  year={2017}
}
Photodynamic therapy (PDT) has emerged as a potent novel therapeutic modality that induces cell death through light-induced activation of photosensitizer. But some photosensitizers have characteristics of poor water-solubility and non-specific tissue distribution. These characteristics become main obstacles of PDT. In this paper, we synthesized a targeting drug delivery system (TDDS) to improve the water-solubility of photosensitizer and enhance the ability of targeted TFR positive tumor cells… CONTINUE READING