Corpus ID: 27581701

Transferred Tumor suppressor BLU inhibits proliferation of nasopharyngeal carcinoma cells by regulation of cell cycle , JNK and cyclin D 1 promoters

@inproceedings{Zhang2012TransferredTS,
  title={Transferred Tumor suppressor BLU inhibits proliferation of nasopharyngeal carcinoma cells by regulation of cell cycle , JNK and cyclin D 1 promoters},
  author={X. Zhang and H. Liu and B. Li and Peichun Huang and J. Shao and Zhiwei He},
  year={2012}
}

X. Zhang, H. Liu, +3 authors Zhiwei He

Published 2012

Background: Tumor suppressor genes are often engaged in signaling pathways to regulate proliferation so as to block growth of tumor cells. To explore the mechanism underlying the tumor suppression activity of BLU/ZMYND10 gene on a frequently lost human chromosomal region, adenoviral vector with BLU cDNA insert was constructed. Methods: BLU gene was re-expressed in nasopharyngeal carcinoma cells by transfection or viral infection. Clonogenic growth was assayed; cell cycle was analyzed by flow… CONTINUE READING

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