Corpus ID: 27581701

Transferred Tumor suppressor BLU inhibits proliferation of nasopharyngeal carcinoma cells by regulation of cell cycle , JNK and cyclin D 1 promoters

@inproceedings{Zhang2012TransferredTS,
  title={Transferred Tumor suppressor BLU inhibits proliferation of nasopharyngeal carcinoma cells by regulation of cell cycle , JNK and cyclin D 1 promoters},
  author={X. Zhang and H. Liu and B. Li and Peichun Huang and J. Shao and Zhiwei He},
  year={2012}
}
  • X. Zhang, H. Liu, +3 authors Zhiwei He
  • Published 2012
  • Background: Tumor suppressor genes are often engaged in signaling pathways to regulate proliferation so as to block growth of tumor cells. To explore the mechanism underlying the tumor suppression activity of BLU/ZMYND10 gene on a frequently lost human chromosomal region, adenoviral vector with BLU cDNA insert was constructed. Methods: BLU gene was re-expressed in nasopharyngeal carcinoma cells by transfection or viral infection. Clonogenic growth was assayed; cell cycle was analyzed by flow… CONTINUE READING

    Figures from this paper

    References

    SHOWING 1-10 OF 21 REFERENCES
    RASSF1A suppresses melanoma development by modulating apoptosis and cell‐cycle progression
    • 38
    The RASSF1A Tumor Suppressor Blocks Cell Cycle Progression and Inhibits Cyclin D1 Accumulation
    • 390
    • PDF
    Gene therapy for human nasopharyngeal carcinoma by adenovirus-mediated transfer of human p53, GM-CSF, and B7-1 genes in a mouse xenograft tumor model.
    • 9
    Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers
    • 106
    • PDF
    Functional studies of the chromosome 3p21.3 candidate tumor suppressor gene BLU/ZMYND10 in nasopharyngeal carcinoma
    • 49
    Tumor-targeted gene therapy for nasopharyngeal carcinoma.
    • 72
    Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo.
    • 182
    • Highly Influential
    • PDF
    Transforming p21ras Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions (*)
    • 861
    • Highly Influential
    • PDF
    RASSF1A suppresses the c-Jun-NH2-kinase pathway and inhibits cell cycle progression.
    • 74
    • PDF