Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel beta-lactamase.

@article{Sirot1987TransferableRT,
  title={Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel beta-lactamase.},
  author={Danielle Sirot and J. Sirot and R. Labia and Ana Morand and Patrice Courvalin and Arlette Darfeuille-Michaud and R Perroux and Roger Cluzel},
  journal={The Journal of antimicrobial chemotherapy},
  year={1987},
  volume={20 3},
  pages={323-34}
}
Approximately 10% (89 isolates) of Klebsiella pneumoniae isolated in 1985 from patients in intensive care units in Clermont-Ferrand exhibited a complex resistance phenotype towards antibiotics. They were resistant to amino-, carboxy- and ureidopenicillins, aminoglycosides (except gentamicin), chloramphenicol, sulphonamides, tetracyclines and, most importantly, to cephalosporins (except cefoxitin and latamoxef) and to aztreonam. The metabolic profile of fifty isolates was identical and seven… CONTINUE READING
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